The protein family known as the Aurora kinase family, which includes the members Aurora A and Aurora B, is crucial for the cell cycle and other cellular functions. Although both Aurora A and Aurora B are involved in controlling the cell cycle, they serve different purposes and are active at various times.
The early phases of cell division are impacted by Aurora A, which is also necessary for the mitotic spindle to develop. Additionally, it controls centrosomes, which are tiny organelles that assist in structuring the mitotic spindle. A possible target for cancer therapy is Aurora A, which is often overexpressed in cancer cells.
Aurora B has a role in the final stages of cell division, including the process of separating the chromosomes and the creation of the mitotic spindle, among other things. It is necessary for the correct segregation of the chromosomes during cell division and is also involved in the control of the centrosomes. Aurora B, which participates in the last phases of cell division, is triggered after Aurora A.
Aurora A and Aurora B are engaged in the control of other cellular processes in addition to their involvement in the cell cycle. The organization of the cytoskeleton, the network of proteins that aids in maintaining the form and structure of cells, and the control of cell migration have both been linked to Aurora A. Additionally, it controls the mitotic checkpoint, which ensures that the chromosomes are correctly positioned before cell division can begin.
Aurora B is not only involved in the control of chromosomal segregation and centrosome activity, but it is also involved in the regulation of other cellular processes. It has been shown to be important for the appropriate segregation of the chromosomes during cell division and to regulate the mitotic spindle.
Overall, the Aurora kinases family consists of two members, Aurora A and Aurora B, who each play a specific role in the cell cycle and other cellular activities. While both kinases have a role in controlling the cell cycle, they are active at various points and play distinct functions throughout cell division. It is essential to have a firm grasp of the distinctions that exist between Aurora A and Aurora B in order to have a firm grasp on the function that these kinases play in both health and illness as well as the development of targeted therapeutics.