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Pain Response
To begin, when a person experiences rejection, this can increase activity in the part of the brain that registers pain. Usually the pain of rejection goes away but in extreme cases, such as a rejection of love, the pain may last for a long time
An example of this in the novel, The Scarlet Letter, is Dimmesdale who, upon hiding his secret for fear of rejection, experienced a chronic and nearly crippling pain.
This response can cause a person to become extremely moody or even fall into a depression