Evidence

Published on Jun 11, 2018

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PRESENTATION OUTLINE

GB34

Yang Hill Spring

GB34
Location: On the lat aspect of the lower leg, in the depression ant & inf to the head of the fibula.

He - Sea point of the GB Meridian
Converging point of Sinews

Indications: Hemiplegia, shoulder pain, weakness & numbness, lower extremities pain, knee swelling & pain, beriberi, hypochondrium pain, bitter taste, vomiting, jaundice, Infantile convulsion

Functions: Benefits sinews & joints, activates meridians, moves LV Qi, harmonizes Shaoyang, relieves pain.

Photo by Pilottage

Notes: GB 34 is a very good point to move Liver Qi and to treat anything related to the sinews. He-Sea points are where the qi of the meridian collects and goes deep into the body. He-sea points are known to indicated treat rebellious qi and diarrhea.
Needling: Perpendicular insertion 1.0 - 1.5 cun

Photo by duncan

Objective: To explore the central mechanism of acupuncture points for regional homogeneity (ReHo) of resting state in brain function after acupuncture at GB34.

Study Says: It is demonstrated that the signal synchronization change ReHo in different brain regions including cognitive, motor, default network, limbic system and other parts of encephalic region after acupuncture at GB34, suggesting that the central mechanism of acupuncture at GB34 is the result of all levels of the combined effects of brain networks.

Def Connectomes: As originally defined by Sporns & colleagues (2005), it is “a comprehensive structural description of the network of elements & connections forming the human brain,” which could be considered either at a “macroscale [of] brain regions & pathways” or a “microscale [of] single neurons & synapses.”

Neuroscientist. 2016 Oct; 22(5): 486–505.
Published online 2015 Jul 13. doi: [10.1177/1073858415595004]
PMCID: PMC5021216
PMID: 26170004
Regional Homogeneity
A Multimodal, Multiscale Neuroimaging Marker of the Human Connectome
Lili Jiang1,2 and Xi-Nian Zuo1,2,3,4

Def Connectomes: As originally defined by Sporns & colleagues (2005), it is “a comprehensive structural description of the network of elements & connections forming the human brain,” which could be considered either at a “macroscale [of] brain regions & pathways” or a “microscale [of] single neurons & synapses.”

Methods: Ten healthy volunteers were enrolled, which included 4 males & 6 females, aged 20–34 years old with median age of 23. The GE Signa HDxt 3.0 T magnetic resonance imaging were performed before (control group) & after acupuncture at GB34, & differences of different brain ReHo of 2 groups by statistical parametric mapping (SPM8) software & ReHo data processing methods were analyzed. The statistically different brain regions were obtained by false discovery rate corrected (FDR-Corrected).

Cerebral activation effects of acupuncture at Yanglinquan(GB34) point acquired using resting-state fMRI
Author links open overlay panelLianshengLiuaShuqiChenaDaohuiZengaHengguoLibChangzhengShibLihongZhangc
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https://doi.org/10.1016/j.compmedimag.2018.04.004

Methods: Ten healthy volunteers were enrolled, which included 4 males & 6 females, aged 20–34 years old with median age of 23. The GE Signa HDxt 3.0 T magnetic resonance imaging were performed before (control group) & after acupuncture at GB34, & differences of different brain ReHo of 2 groups by statistical parametric mapping (SPM8) software & ReHo data processing methods were analyzed. The statistically different brain regions were obtained by false discovery rate corrected (FDR-Corrected).

Study Flaw: Only 10 participants

Results: Compared with control group, the ant. cingulated gyrus, left temp gyrus, right inf. parietal lobule, right frontal gyrus were enhanced ReHo after acupuncture at GB34. The left thalamus, right insular cortex, left inf. frontal gyrus, right ant. cingulate were decreased ReHo after acupuncture at GB34.

the ReHo method introduced by Zang & colleagues is increasingly recognized as a highly sensitive, reproducible, & reliable neuroimaging marker to characterize the human brain according to its local functional organization as well as its relationships with network-level characteristics.

Neuron. Author manuscript; available in PMC 2013 Dec 31.
Published in final edited form as:
Neuron. 2012 Jul 26; 75(2): 10.1016/j.neuron.2012.06.031.
doi: [10.1016/j.neuron.2012.06.031]
PMCID: PMC3876951
NIHMSID: NIHMS395209
PMID: 22841307
From functional architecture to functional connectomics
R.Clay Reid

Background Acupuncture and related techniques are used worldwide to alleviate pain; however, their mechanisms of action are still not fully understood. In the present study, we investigated the effect of transcutaneous electrical acupuncture point stimulation (TEAS) at different frequencies in a chronic constriction injury (CCI) model of neuropathic pain in rats.

Effect of transcutaneous electrical acupuncture point stimulation at different frequencies in a rat model of neuropathic pain
Xiangdi Yu, Fangxiang Zhang, Bingning Chen
Author affiliations
Department of Anaesthesiology, Guizhou Provincial People's Hospital, Guiyang, China
Correspondence to
Dr X Yu, Department of Anaesthesiology, Guizhou Provincial People's Hospital, Zhongshan Eastern Road No 83, Guiyang, Guizhou 550002, China; Xiangdi_Yu@163.com

Methods CCI was induced by ligating the common sciatic nerve, which produced neuropathic pain. 18 male Sprague–Dawley rats with CCI were randomly divided into three groups (n=6 each) that remained untreated (CCI group) or received TEAS at high frequency (CCI+TEAS-H group) or TEAS at low frequency (CCI+TEAS-L group). Rats in the CCI+TEAS-H group received high frequency stimulation (6–9 mA, 100 Hz) at GB34/GV26/ST36; those in the CCI+TEAS-L group received low frequency stimulation (6–9 mA, 2 Hz) at the same points. Rats in the control group had the same electrodes applied but received no stimulation. All three groups were subjected to behavioural studies after treatment. Expression of μ opioid receptors (MORs) in the L3–L5 dorsal root ganglion (DRG) was determined by immunofluorescence staining and Western blotting after treatment.

Results Compared with the untreated CCI group, both mechanical allodynia and thermal hypergesia were significantly attenuated, and MOR expression in the DRG was significantly increased by low frequency TEAS treatment at GB34/GV26/ST36 (p

Conclusions The use of low frequency TEAS significantly mitigated neuropathic pain in this rat model, and its analgesic effect is likely mediated by upregulation of MOR expression in the DRG.