Title
Published on Nov 21, 2015
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MORE DECKS TO EXPLORE
PRESENTATION OUTLINE
AN ACUTE PHASE PROTEIN
Photo by Argonne National Laboratory
NEUTRALIZES THE OXIDATIVE ACTIVITY OF HEMOGLOBIN
ESSENTIAL IN INCIDENCES OF INTRAVASCULAR HEMOLYSIS
Mechanism
CD163 macrophage MEDIATES ENDOCYTOSIS OF HP-HB COMPLEX
What has research shown so far?
"HP PHENOTYPE IS AN INDEPENDENT RISK FACTOR FOR CARDIOVASCULAR DISEASE IN INDIVIDUALS WITH Dm"
THE STRONG HEART STUDY
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"Haptoglobin: a major susceptibility gene for dm vascular complications"
Tal SZAFRANEK, Stuart MARSH, ANDREW P. LEVY
Photo by euthman
"HP POLYMORPHISM PREDICTS 30-DAY MORTALITY AND HEART FAILURE IN PATIENTS WITH DM AND AMI"
Mahmoud suleiman, doron aronson, rabea asleh
"haptoglobin genotype predicts development of coronary artery calcification in patients with type-1 dm"
Melissa simpson, janet k. snell-bergeon, Gregory l. kinney
"HP GENOTYPE IS PREDICTIVE OF MAJOR ADVERSE CARDIAC EVENTS IN THE 1-YEAR PERIOD AFTER PTCA IN INDIVIDUALS WITH DM."
ARIEL ROUGIN, WERner koch, adnan kastrati
Photo by denn
WHAT gENOTYPE AND WHY?
Hp2-2
But how does this all fit in with CT surgery?
relevant complications of CABG
Atrial fibrillation, ventricular tachycardia, renal failure
Photo by Nottingham Vet School
consider this...
"hemolysis is a fact in all extracorporeal circuits...by increasing levels of plasma-free Hb and decreasing levels of Hp during and after cpb."
vercaemst l. (university hospital gasthuisberg, belgium)
"...tubular injury resulting from heme proteins should be considered as a cause of decreased kidney function in all patients with a cardiac valvular disease or prosthesis."
QIAN Q. PUB MED (THE MAYO CLINIC)
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DOES HP PHENOTYPE PREDICT THE INCIDENCE OF POST-OP RENAL FAILURE?
wide range of applications in surgical context
HYPOTHETICAL FOCUS essentially INTERCHANGEABLE
DOES HAPTOGLOBIN PHENOTYPE PREDICT THE INCIDENCE OF POST-OPRATIVE___________?
the FUTURE
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