PARKINSON

WHAT IS/WHY

• Movement disorder
• When is not enough dopamine.

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SYMPTOMS

• Gradually start.
• Affect one side first
• Tremblings of members, jawline and face.
• Stiffness of arms or legs
• Slowness of movements
• Poor balance/coordination.

DOPAMINE

• Is a neurotransmitter released by the brain that have several roles in humans and animals
• Is produced in the hypothalamus, dopaminergic neurons and VTA.

DOPAMINE IN MOVEMENTS

• A part of the brain called the basal ganglia regulates the movements. It depends on a certain amount of dopamine.
• Less/excessive dopamine is bad.

PLEASURE REWARD

• Dopamine is in charge of the pleasure. This means food, sex, and several drugs of abuse are also stimulants of dopamine, particularly in areas such as the nucleus accumbens and prefrontal cortex.

IN MEMORY

• Dopamine works in the prefrontal cortex to improve memory.
• But the balance is specific, and increase or decrease may affect the memory.

DOPAMINE AND DRUGS

• Cocaine and amphetamines inhibit the re-uptake of dopamine.

MORE RELATED PROBLEMS

• Attention
• Cognition
• Social functioning
• Psychosis
• Pain Processing.

GETS DIFFICULT

• As symptoms get worse, people with the disease may have trouble walking, talking, or doing simple tasks. They may also have problems such as depression, sleep problems, or trouble chewing, swallowing, or speaking.

NO CURE/MEDICATION

• PD usually begins around age 60, but it can start earlier. It is more common in men than in women. There is no cure for PD. A variety of medicines sometimes help symptoms dramatically. The most effective treatment is the L-Dopa

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• Surgery and deep brain stimulation (DBS) can help severe cases. With DBS, electrodes are surgically implanted in the brain. They send electrical pulses to stimulate the parts of the brain that control movement.