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Sildenafil

Sildenafil

• Originally developed by Pfizer for the treatment of high blood pressure and angina pectoris.
• During the clinical trials the researchers discovered that the drug was more effective at inducing erections than treating angina.

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Minoxidil

• Minoxidil was developed as a antihypertensive agent.
• During clinical trials they identified that patients were getting a bit hairy.
• In 1980 an open letter to the NEJM by Anthony R. Zappacosta put paid to the pharmaceutical company keeping this a secret.
• It's now the active ingredient in Regaine Topical solution.

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Research may not always go the way you expected it to.

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Radiographer Reporting

• This meta-analysis by Brealey et al demonstrates a summary sensitivity of radiographer reporting of 92.6% (95% CI: 92.0, 93.2), with a specificity of 97.7% (95% CI: 97.5, 97.9).
• ROC curves indicated that radiographer reporting accuracy in clinical practice was comparable to that of the reference standard.

Benefits to the Profession

Benefits to the individual

Benefits to the individual

• Personal development from learning and developing new theories, approaches or techniques.
• Satisfaction of improving services or care.
• Opportunities to network with others beyond your institution.

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START Trial

START Trial Results

• 40 Gy in 15# was as good as 50Gy in 25#.
• At ten years follow-up less breast oedema, breast shrinkage and telangectasia was significantly less common in the shorter fractionation group.

Career in Research

• Completed my PhD while a clinical superintendent in Leeds.
• Moved to Sheffield Hallam as a post doc.

Career in Research

• Reader in Radiotherapy in 2013.
• Professor of Radiotherapy and Oncology in 2015.

Benefit to patients

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Tweet me @HeidiProbst