The illness known as the dancing plague of 1518 originated in the city of Strasbourg, then spread to parts of the Roman Empire. Victims of the illness where struck by a sudden and seemingly uncontrollable urge to dance. The first known victim was a women known as Frau Troffea. She stepped into the street and began to silently dance.
Frau Troffea kept up her dance for nearly a week. After that three-dozen other Strasbourgeois had joined her. By August, the dancing illness had claimed about 400 victims. The town had hired a band for the victims of the illness. It wasn’t long before the illness started to take its toll. Many dancers collapsed from sheer exhaustion. Some died from strokes and heart attacks. Theories have suggested the dancers had accidentally ingested ergot, a toxic mold that grows on moist rye and can produce spasms and hallucinations.