Collagen

General Awareness

• Falsity of collagen-based product industry
• Arthritis & cosmetics
• Nutritional benefits

Discovery

• Evidence of a regular structure
• Search for the collagen monomer

Early Uses

• Glue used as protective lining and to hold utensils together
• Egyptians and Native Americans

What is collagen?

• Protein that makes up 25-35%
• Important structurally and functionally
• Half life of 117 years
• Covalent with many hydrogen bonds
• Triple helix structure, composed of glycine, proline, and hydroxyproline
• C2H5NOC5H9NOC5H10NO2

Extraction Sources

• Human
• Bovine, porcine, equine, ovine sources
• Found in bones, skin, muscles, & tendons

Role of Collagen

• Structural support, strength, and elasticity
• Protective coverings
• Fibrous network in the dermis
• Replacement and restoration of dead skin cells

Uses in Food

• Soy, lemons (scurvy), dark green vegetables, red fruits, vitamin C, turkey, flaxseed
• Gelatin (hydrolyzed collagen)

Glycine [C2H5NO2]

Proline [C5H9NO2]

Synthesis of Collagen

• Biological synthesis
• Genes specific to collagen type
• mRNA processing
• Translation
• Post-translational modifications to pro-collagen
• Crosslink formation

Collagen Worldwide

• Worldwide demand in 2013 was 3.75 Kilo tons and had its major application in food industry
• Europe is the largest collagen producing market, contributing 35% share of the total market
• China has been the major consuming market, predicts double digit growth from 2015-2020

Negative impacts/ Disadvantages

• High cost of pure type I collagen
• High risk in transmitting illnessess

Medical Importance

• Skin fillers
• Wound dressings
• Tissue regeneration
• Vascular prosthetics
• Arthritis
• Cosmetic products

Toxicity

• Experimental toxicity in rabbits
• Respiratory distress, agitation, convulsions, death
• Damage occurred to lungs and liver of animals

www.comprehendcollagen.weebly.com

Sources

Collagen's Molecular Structure: http://www.slideshare.net/nashton/collagen-5444601
Chemistry About: http://chemistry.about.com/od/polymers/a/Collagen.htm
Medical News Today: http://www.medicalnewstoday.com/articles/262881.php#medical_uses

News Medical:
http://www.news-medical.net/health/Collagen-Uses.aspx
Chemistry Explained: http://www.chemistryexplained.com/Ce-Co/Collagen.html
Medscape: http://www.medscape.com/viewarticle/423231_2

NCBI: http://www.ncbi.nlm.nih.gov/books/NBK21582/
Orthobullets http://www.orthobullets.com/basic-science/9013/collagen


Lagowski, J. J. "Collagen." Chemistry: Foundations and Applications. New York: Macmillan Reference USA, 2004. Print.