1 of 8

Slide Notes

DownloadGo Live

CLL

To understand Chronic Lymphocytic Leukemia you have to understand cancer first ....

PRESENTATION OUTLINE

Chronic Lymphocytic Leukemia

PHM111 Course Project

CLL

  • Chronic lymphocytic leukemia is a type of cancer that starts from cells that become certain white blood cells, called lymphocytes, in the bone marrow.
The cancer cells start in the bone marrow but then it goes into the blood. The leukemia cells often build up slowly over time, and many people don't have any symptoms for at least a couple of years.

THE EXACT CAUSE OF CHRONIC LYMPHOCYTIC LEUKEMIA IS NOT KNOWN. We know that there is some kind of inherited genetic change in some people who develop

CLL.

Studies show that people with a parent or sibling with CLL have a 6 to 9 times increased risk of developing it themselves.

It is very uncommon in people from China, Japan, or Southeast Asian countries. It is more common in white people than black people but unfortunately the reasons for these differences are not known.

For many years, chlorambucil with or without corticosteroids was used in
previously untreated patients with CLL.

RECENT STUDIES

  • More recently, purine nucleoside analogues (PNAs) such as fludarabine, cladribine, and pentostatin have been included in treatment approaches for this disease, and chlorambucil is no longer the leading standard everywhere.
Fludarabine (Fludara and Oforta),

Cladribine (Leustatin), and

Pentostatin (Nipent) are anti-cancer,

"antineoplastic" or "cytotoxic", chemotherapy drugs. 

~ These medications are classified as an
antimetabolite. All three are given through a vein, intravenously. ~

The American Cancer Society's estimates for CLL in the United States for 2017 are about 20,110 new cases and about 4,660 deaths from Chronic Lymphocytic Leukemia.

CLL is not yet curable

but steps are being taken to further find the right cure.