Albumin is made in hepatocytes at a rate of 200 mg/kg/day

Total body albumin is 4-5 g/kg

40-45% of albumin is in the intravascular space

Albumin concentration in the interstitial space is 0.7g/dL in fat and
1.3g/dL in skeletal muscle

Albumin has a half life of 2 to 3 weeks

Albumin falls with inflammation due to:
reduced synthesis and
increased fractional catabolic rate (FCR)

Intradialytic weight gain of 2.8 liters (4% of 70 kg) will dilute albumin by 0.8 g/dL

references

• Improving albumin levels among hemodialysis patients (PubMed)
• Measurement of interstitial albumin in human skeletal muscle and adipose tissue by open-flow micro perfusion (PubMed)