The Laboratory

Published on Jan 24, 2016

A simplistic overview of my research interests. Offers of collaboration and studentship/postdoctoral enquiries gladly received. Please e-mail: karen.anthony@northampton.ac.uk

PRESENTATION OUTLINE

The Laboratory

a story about my research in 12 facts
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the molecular mechanisms of neurological disease

i research
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a group of disorders called the tauopathies

the story begins with
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alzheimer's disease

this includes

potential drug targets

i have identified and characterised
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(that bit between dna and protein)

 based around rna metabolism
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to a neuromuscular disorder

i applied my rna expertise
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duchenne muscular dystrophy (dmd)

called

for an rna-based gene therapy

i worked on DMD clinical trials

undergoing review to bring it to market

the drug candidate is currently
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i have two areas of research....

with rna as a unifying theme

1. neurodegeneration

  • Regulation of neuronal RNA processing
  • Identification and characterisation of neuronal RNA-binding proteins
  • Proof-of-concept and pre-clinical development of novel RNA-based therapeutic strategies
  • Disease-associated genes of interest include MAPT, TARDBP, FUS and C9ORF72
Photo by Grey cells

2. neuromuscular disorders

  • Pre-clinical and clinical studies to develop antisense oligonucleotide-mediated exon skipping as a therapy for DMD
  • Biochemical characterisation of Becker muscular dystrophy
  • Function and therapeutic targeting of dystrophin in the brain
  • RNA processing of the DMD gene

would you like to hear more of the story?